Fine needle aspiration cytology fnac is an established out patient procedure used in primary diagnosis of palpable thyroid lesions a modified technique fine needle capillary sampling fncs obviates the need of suction is less painful patient friendly and reported to overcome the problem of inadequate and bloody specimens. Broadsheet number 57 problems in fine needle biopsy of the thyroid fine needle biopsy and cytological diagnosis of thyroid lesions monographs in clinical cytology vol 14 basel karger 1997 5 li volsi va merino mj worrisome histologic alterations following fine needle aspiration of the thyroid. Background fine needle aspiration cytology fnac and fine needle nonaspiration cytology fnnac are useful cost effective techniques for preoperatively assessing thyroid lesions both techniques have advantages and disadvantages and there is controversy over which method is superior this meta analysis was performed to evaluate the differences between fnac and fnnac for diagnosis of thyroid . While thyroid biopsy is the most accurate method to differentiate between benign and cancerous thyroid nodules up to 18 are indeterminate in which a definitive diagnosis cannot be made the aim of this study was to determine whether several features cytology features ultrasound appearance of the thyroid nodules and the presence of the braf v600e mutation are helpful to predict cancer in
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