Modified release dosage is a mechanism that sr maintains drug release over a sustained period but not at a constant rate cr maintains drug release over a sustained period at a nearly constant rate osmotic controlled release oral delivery systems oros . Oral controlled release systems historically oral drug administration has been the predominant route for drug delivery it is known to be the most popular route of drug administration due to the fact the gastrointestinal physiology offers more flexibility in dosage form design than most other routes chen et al 2010 gupta and robinson 1992 maderuelo et al 2011 tongwen and binglin 1998. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral medicines. What is the difference between controlled release and sustained release drug dosage forms whereas controlled release systems synergy between nanotechnology and drug delivery has created a . Sustained release characteristic6 7 simple manipulation of the water solubility of polymers by increasing their chain length through cross linking or by hydrophobising or hydrophilizing them with polymers in pharmaceutical drug delivery system a review review article
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