Addresses the key topic in combinatorial synthesis how to optimize the quality of a combinatorial library by determining the usefulness of synthesized compunds the reliability of biological assay results and analyzing acadmic and industrial applications real world examples and case studies of successful and unsuccessful technologies. Current combinatorial chemistry and solid phase synthesis each topic may be addressed by a short presentation 12 15 min and discussed by the seminars participants 1 history of combinatorial chemistry ref xiii pp9 citated literature 2 principles of combinatorial chemistry ref i pp 1 34 3 resins for solid phase synthesis. A system for the development and production of small molecule libraries armen m boldi charles r johnson quality control of combinatorial libraries encoded with electrophoric tags a case study roland e dolle how to optimize reactions for solid phase synthesis of combinatorial libraries using rf tagged microreactors rongshi li . The principles and practice of solid phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides a parallel synthesis scheme is used to generate a series of tripeptides a divergent synthesis scheme is used to prepare two pentapeptides one of which is leucine enkephalin a neurotransmitter known to be an analgesic agent
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